Arnulfo Rubio smuggles weapons for a deadly Mexican cartel. ATF agent Hank Harris attempts to apprehend him, but gets kidnapped by Rubio, instead. Rubio takes him to his bosses, but during the 600-miles-long drive, they slowly befriend.
The familiar tragic story of Vincent van Gogh is broadened by focusing as well on his brother Theodore, who helped support Vincent. The movie also provides a nice view of the locations which Vincent painted.